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Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets.

Abstract:

OBJECTIVE: Triomune Baby and Junior have been developed in response to the urgent need for appropriate paediatric fixed-dose combination antiretroviral tablets, with higher nevirapine to stavudine and lamivudine ratios than adult tablets, in accordance with paediatric recommendations. We determined whether this ratio results in optimal exposure in the target population. METHODS: Seventy-one Zambian children were treated with Triomune Baby or Junior dosed according to weight bands. After 4 wee...

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Publication status:
Published

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Journal:
AIDS (London, England)
Volume:
22
Issue:
5
Pages:
557-565
Publication date:
2008-03-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:51d6bd26-8192-422d-a741-c621d416744d
Source identifiers:
422943
Local pid:
pubs:422943

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