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Regulation of intracellular pH in sheep cardiac Purkinje fibre: interactions among Na+, H+, and Ca2+1.

Abstract:

Experiments were performed on sheep cardiac Purkinje fibres using pH- and sodium-selective microelectrodes, while simultaneously measuring tension, to determine if the fall in intracellular pH (pHi) following a rise in intracellular Na+ activity (aiNa) is caused by inhibition or reversal of acid extrusion on Na+-H+ exchange. A rise in aiNa was induced either by using the cardioactive steroid strophanthidin to inhibit the sarcolemmal Na+-K+ pump or by increasing the frequency of stimulation (0...

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Publication status:
Published

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Publisher copy:
10.1139/y87-153

Authors


Vaughan-Jones, RD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Canadian journal of physiology and pharmacology
Volume:
65
Issue:
5
Pages:
963-969
Publication date:
1987-05-05
DOI:
EISSN:
1205-7541
ISSN:
0008-4212
URN:
uuid:51d6a11d-704e-4828-a3fe-17218582c7b8
Source identifiers:
35353
Local pid:
pubs:35353

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