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Investigating strategies to modify PARP14 function through macrodomain inhibition

Abstract:

Macrodomains are conserved protein interaction modules that are present in all domains of life and mediate recognition of sequence motifs harbouring adenosine diphosphate ribose (ADPR) modifications. In addition, some of them are able to control the turnover of ADPR signalling through their catalytic activity removing these modifications. Macrodomains are hence implicated in a variety of cellular processes as well as in diseases including cancer and viral pathogenesis. The polyadenosine-di...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Schuller, M
Grant:
1368548
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:51a76ee9-609a-4765-ab55-d95a64e2bb7d
Deposit date:
2018-07-29

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