Thesis icon

Thesis

Investigating strategies to modify PARP14 function through macrodomain inhibition

Abstract:

Macrodomains are conserved protein interaction modules that are present in all domains of life and mediate recognition of sequence motifs harbouring adenosine diphosphate ribose (ADPR) modifications. In addition, some of them are able to control the turnover of ADPR signalling through their catalytic activity removing these modifications. Macrodomains are hence implicated in a variety of cellular processes as well as in diseases including cancer and viral pathogenesis. The polyadenosine-di...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Department:
Oxford, MSD, NDM

Contributors

More from this funder
Grant:
1368548
Funding agency for:
Marion Schuller
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP