Journal article

Immunomodulation in multiple sclerosis: promises and pitfalls

Abstract:: Multiple sclerosis (MS) afflicts about 2.5 million people globally and poses a major personal and socioeconomic burden. The recognition of MS as an inflammatory disease, characterized by infiltration of immune cells into the central nervous system, has spurred research into the autoimmune etiology of the condition and has provided the rationale for its treatment through immunomodulation. Experience with immunotherapies in MS to date has suggested a disparity between the observed immune cell infiltration and the progressive loss of neurons. However, recent clinical efforts are providing new insights into progressive MS that once again place the immune system at center stage. This article reviews the main mechanisms of MS immunopathogenesis, and the benefits, risks and challenges of immunomodulatory treatments for the disease.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Dendrou, C., & Fugger, L. (2017). Immunomodulation in multiple sclerosis: promises and pitfalls. Current Opinion in Immunology, 49, 37–43.

MLA Style

Dendrou, C., and L. Fugger. “Immunomodulation in Multiple Sclerosis: Promises and Pitfalls.” Current Opinion in Immunology, vol. 49, Elsevier, 2017, pp. 37–43.

Chicago Style

Dendrou, C, and L Fugger. 2017. “Immunomodulation in Multiple Sclerosis: Promises and Pitfalls.” Current Opinion in Immunology 49: 37–43.
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Files:: COIMMU_2017_59_Multiple_sclerosis_Manuscript.pdf

(Preview, Accepted manuscript, pdf, 122.7KB, Terms of use)

Publisher copy:: 10.1016/j.coi.2017.08.013

Authors

+ Dendrou, C More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Role:: Author

+ Fugger, L More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Clinical Neurosciences
Role:: Author

+ Oak Foundation More from this funder

Grant:: OCAY-15-520 to L.F

+ Medical Research Council More from this funder

Grant:: MC_UU_12010/3 to L.F

+ Danish National Research Foundation More from this funder

Grant:: 126 to L.F

+ Wellcome Trust More from this funder

Grant:: 100308/Z/12/Z to L.F

+ Wellcome Trust/Royal Society More from this funder

Grant:: 204290/Z/16/Z to C.A.D

Publisher:: Elsevier
Journal:: Current Opinion in Immunology More from this journal
Volume:: 49
Pages:: 37-43
Publication date:: 2017-09-18
DOI:: 10.1016/j.coi.2017.08.013
EISSN:: 1879-0372
ISSN:: 0952-7915
Pmid:: 28926740

Language:: English
Pubs id:: pubs:730108
UUID:: uuid:5199e437-5a5c-48cb-89b4-57dd858d8ac1
Local pid:: pubs:730108
Source identifiers:: 730108
Deposit date:: 2017-12-05

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2017
Notes:: Copyright © 2017 Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.coi.2017.08.013

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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