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Bacterial actin: architecture of the ParMRC plasmid DNA partitioning complex.

Abstract:

The R1 plasmid employs ATP-driven polymerisation of the actin-like protein ParM to move newly replicated DNA to opposite poles of a bacterial cell. This process is essential for ensuring accurate segregation of the low-copy number plasmid and is the best characterised example of DNA partitioning in prokaryotes. In vivo, ParM only forms long filaments when capped at both ends by attachment to a centromere-like region parC, through a small DNA-binding protein ParR. Here, we present biochemical ...

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Publisher copy:
10.1038/emboj.2008.152

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
The EMBO journal
Volume:
27
Issue:
16
Pages:
2230-2238
Publication date:
2008-08-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:5197112b-e32c-4e49-bfd4-908719cee587
Source identifiers:
432092
Local pid:
pubs:432092

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