Journal article
Physiology-based regularization of the electrocardiographic inverse problem
- Abstract:
- The inverse problem of electrocardiography aims at noninvasively reconstructing electrical activity of the heart from recorded body-surface electrocardiograms. A crucial step is regularization, which deals with ill-posedness of the problem by imposing constraints on the possible solutions. We developed a regularization method that includes electrophysiological input. Body-surface potentials are recorded and a computed tomography scan is performed to obtain the torso–heart geometry. Propagating waveforms originating from several positions at the heart are simulated and used to generate a set of basis vectors representing spatial distributions of potentials on the heart surface. The real heart-surface potentials are then reconstructed from the recorded body-surface potentials by finding a sparse representation in terms of this basis. This method, which we named ‘physiology-based regularization’ (PBR), was compared to traditional Tikhonov regularization and validated using in vivo recordings in dogs. PBR recovered details of heart-surface electrograms that were lost with traditional regularization, attained higher correlation coefficients and led to improved estimation of recovery times. The best results were obtained by including approximate knowledge about the beat origin in the PBR basis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.7MB, Terms of use)
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- Publisher copy:
- 10.1007/s11517-016-1595-5
Authors
- Publisher:
- Springer Verlag
- Journal:
- Medical & Biological Engineering & Computing More from this journal
- Volume:
- 55
- Issue:
- 8
- Pages:
- 1353–1365
- Publication date:
- 2016-11-21
- Acceptance date:
- 2016-10-26
- DOI:
- EISSN:
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1741-0444
- ISSN:
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0140-0118
- Pmid:
-
27873155
- Language:
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English
- Keywords:
- Pubs id:
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pubs:693358
- UUID:
-
uuid:5193cc42-da61-40c3-9e47-7e148e0fe164
- Local pid:
-
pubs:693358
- Source identifiers:
-
693358
- Deposit date:
-
2019-01-24
Terms of use
- Copyright holder:
- Cluitmans et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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