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Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment

Abstract:

A significant proportion of children have unexplained problems acquiring proficient linguistic skills despite adequate intelligence and opportunity. Developmental language disorders are highly heritable with substantial societal impact. Molecular studies have begun to identify candidate loci, but much of the underlying genetic architecture remains undetermined. We performed whole-exome sequencing of 43 unrelated probands affected by severe specific language impairment, followed by independent...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep46105

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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Max Planck Society More from this funder
Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Article number:
46105
Publication date:
2017-04-25
Acceptance date:
2017-03-08
DOI:
EISSN:
2045-2322
Pmid:
28440294
Source identifiers:
692244
Language:
English
Keywords:
Pubs id:
pubs:692244
UUID:
uuid:518c8ba0-aec3-460d-acfd-60e802ee7a59
Local pid:
pubs:692244
Deposit date:
2018-11-22

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