Journal article : Review
The unappreciated generative role of cell movements in pattern formation
- Abstract:
- The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 960.9KB, Terms of use)
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- Publisher copy:
- 10.1098/rsos.211293
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 109408/Z/15/Z
- Publisher:
- The Royal Society
- Journal:
- Royal Society Open Science More from this journal
- Volume:
- 9
- Issue:
- 4
- Article number:
- 211293
- Place of publication:
- England
- Publication date:
- 2022-04-27
- Acceptance date:
- 2022-04-05
- DOI:
- EISSN:
-
2054-5703
- Pmid:
-
35601454
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1259697
- Local pid:
-
pubs:1259697
- Deposit date:
-
2025-05-01
- ARK identifier:
Terms of use
- Copyright holder:
- Fulton et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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