Journal article

Polygenic risk scores and embryonic screening: considerations for regulation

Abstract:: Polygenic risk scores (PRSs) have recently been used to inform reproductive decision-making in the context of embryonic screening. While this is yet to be widespread, it is contested and raises several challenges. This article provides an overview of some of the ethical considerations that arise with using PRSs for embryo screening and offers a series of regulatory considerations for jurisdictions that may wish to permit this in the future. These regulatory considerations cover possible regulators and regulatory tools, eligibility criteria, information and education requirements and the need for ongoing refinement of the relevant technology, research and consultation.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Haining, C. M., Savulescu, J., Keogh, L., & Schaefer, G. O. (2024). Polygenic risk scores and embryonic screening: considerations for regulation. Journal of Medical Ethics, 51(10), 719–728.

MLA Style

Haining, C. M., et al. “Polygenic Risk Scores and Embryonic Screening: Considerations for Regulation.” Journal of Medical Ethics, vol. 51, no. 10, BMJ Publishing Group, 2024, pp. 719–28.

Chicago Style

Haining, CM, J Savulescu, L Keogh, and GO Schaefer. 2024. “Polygenic Risk Scores and Embryonic Screening: Considerations for Regulation.” Journal of Medical Ethics 51 (10): 719–28.
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Files:: Haining_et_al_2024_Polygenic_risk_scores.pdf

(Preview, Version of record, pdf, 363.9KB, Terms of use)

Publisher copy:: 10.1136/jme-2024-110145

Authors

+ Haining, CM More by this author

Role:: Author
ORCID:: 0000-0002-9596-6654

+ Savulescu, J More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Philosophy
Oxford college:: St Cross College
Role:: Author
ORCID:: 0000-0003-1691-6403

+ Keogh, L More by this author

Role:: Author
ORCID:: 0000-0003-2963-6451

+ Schaefer, GO More by this author

Role:: Author
ORCID:: 0000-0002-6915-6148

Publisher:: BMJ Publishing Group
Journal:: Journal of Medical Ethics More from this journal
Volume:: 51
Issue:: 10
Pages:: 719-728
Place of publication:: England
Publication date:: 2024-12-16
Acceptance date:: 2024-11-03
DOI:: 10.1136/jme-2024-110145
EISSN:: 1473-4257
ISSN:: 0306-6800
Pmid:: 39681416

Language:: English
Pubs id:: 2072457
Local pid:: pubs:2072457
Deposit date:: 2025-02-17

Terms of use

Copyright holder:: Haining et al
Copyright date:: 2025
Rights statement:: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made.

Licence:: CC Attribution (CC BY)

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