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A mathematical framework for estimating pathogen transmission fitness and inoculum size using data from a competitive mixtures animal model.

Abstract:

We present a method to measure the relative transmissibility ("transmission fitness") of one strain of a pathogen compared to another. The model is applied to data from "competitive mixtures" experiments in which animals are co-infected with a mixture of two strains. We observe the mixture in each animal over time and over multiple generations of transmission. We use data from influenza experiments in ferrets to demonstrate the approach. Assessment of the relative transmissibility between two...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pcbi.1002026

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Melbourne School of Population Health More from this funder
Australian National Health and Medical Research Council More from this funder
Australian Government Department of Health and Ageing More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS computational biology Journal website
Volume:
7
Issue:
4
Pages:
e1002026
Publication date:
2011-04-05
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
URN:
uuid:51735b08-924b-4927-bc6e-481209f4a500
Source identifiers:
209977
Local pid:
pubs:209977

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