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The structure of genotype-phenotype maps makes fitness landscapes navigable

Abstract:

Fitness landscapes are often described in terms of 'peaks' and 'valleys', indicating an intuitive low-dimensional landscape of the kind encountered in everyday experience. The space of genotypes, however, is extremely high dimensional, which results in counter-intuitive structural properties of genotype-phenotype maps. Here we show that these properties, such as the presence of pervasive neutral networks, make fitness landscapes navigable. For three biologically realistic genotype-phenotype m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41559-022-01867-z

Authors


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Role:
Author
ORCID:
0000-0003-4452-2006
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0002-8438-910X
Publisher:
Springer Nature
Journal:
Nature Ecology and Evolution More from this journal
Volume:
6
Issue:
11
Pages:
1742-1752
Publication date:
2022-09-29
Acceptance date:
2022-08-01
DOI:
EISSN:
2397-334X
Pmid:
36175543
Language:
English
Keywords:
Pubs id:
1285868
Local pid:
pubs:1285868
Deposit date:
2023-04-03

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