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Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae.

Abstract:

We have identified a gene for the addition of N-acetylneuraminic acid (Neu5Ac) in an alpha-2,3-linkage to a lactosyl acceptor moiety of the lipopolysaccharide (LPS) of the human pathogen Haemophilus influenzae. The gene is one that was identified previously as a phase-variable gene known as lic3A. Extracts of H. influenzae, as well as recombinant Escherichia coli strains producing Lic3A, demonstrate sialyltransferase activity in assays using synthetic fluorescent acceptors with a terminal gal...

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Publication status:
Published

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Authors


Gilbert, M More by this author
Makepeace, K More by this author
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Journal:
Molecular microbiology
Volume:
39
Issue:
2
Pages:
341-350
Publication date:
2001-01-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:51603023-d12a-46fb-a099-0a52ff3b90e9
Source identifiers:
115623
Local pid:
pubs:115623

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