- Abstract:
-
CEA TCB is a novel IgG-based T Cell Bispecific antibody for the treatment of CEA-expressing solid tumors currently in Phase 1 clinical trials (NCT02324257). Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA and CD3e binding Fab domains and an engineered Fc region with completely abolished binding to FcγRs and C1q. The study provides novel mechanistic insights into the activity and mode of action of CEA TCB.CEA TCB activity was characterized on 110 cell lines in vit...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 624.5kb)
-
- Publisher copy:
- 10.1158/1078-0432.CCR-15-1696
-
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- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Clinical Cancer Research Journal website
- Volume:
- 22
- Issue:
- 13
- Pages:
- 3286-3297
- Publication date:
- 2016-02-09
- DOI:
- EISSN:
-
1078-0432
- ISSN:
-
1078-0432
- URN:
-
uuid:515dc835-2310-473f-9232-ffed858f0a79
- Source identifiers:
-
606098
- Local pid:
- pubs:606098
- Paper number:
- 13
- Language:
- English
- Keywords:
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2016
- Notes:
- Copyright © 2016, American Association for Cancer Research. This is the accepted manuscript version of the article. The final version is available online from the American Association for Cancer Research at: [10.1158/1078-0432.CCR-15-1696]
Journal article
A novel carcinoembryonic antigen t cell bispecific antibody (cea tcb) for the treatment of solid tumors
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