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Self-organizing & stochastic behaviors during the regeneration of hair stem cells

Abstract:

Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicul...

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Publication date:
2011-01-01
URN:
uuid:515709f8-dd1b-44a6-8dcc-62eead6b7676
Local pid:
oai:eprints.maths.ox.ac.uk:1069

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