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Features of effective T cell-inducing vaccines against chronic viral infections

Abstract:

For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with human immunodeficiency virus, cytomegalovirus, and hepatitis C virus. Currently, various promising prophylactic vaccines, capable of inducing substantial vaccine-specific T cell responses, are investigated in preclinical and clinical studies. There is compellin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.00276

Authors


Panagioti, E More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Oxford college:
Green Templeton College
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
van der Burg, SH More by this author
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Grant:
FP7 Marie Curie Action, Grant number: 316655, VacTrain
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
Article: 276
Publication date:
2018-02-16
Acceptance date:
2018-01-31
DOI:
EISSN:
1664-3224
Pubs id:
pubs:827253
URN:
uri:5134bb24-5f7c-4018-84b1-05e0fd2f227b
UUID:
uuid:5134bb24-5f7c-4018-84b1-05e0fd2f227b
Local pid:
pubs:827253

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