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The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life

Abstract:

BACKGROUND: Recent transcriptomic studies revived a hypothesis suggested by historical studies in rabbits that the ratio of peripheral blood monocytes to lymphocytes (ML) is associated with risk of tuberculosis (TB) disease. Recent data confirmed the hypothesis in cattle and in adults infected with HIV. METHODS: We tested this hypothesis in 1,336 infants (540 HIV-infected, 796 HIV-exposed, uninfected (HEU)) prospectively followed in a randomized controlled trial of isoniazid prophylaxis in So...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s12916-014-0120-7

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author

Contributors

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Funding agency for:
Mcshane, H
Hill, A
More from this funder
Funding agency for:
Naranbhai, V
Bristol-Myers Squibb More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
12
Issue:
1
Pages:
Article no. 120
Publication date:
2014-01-01
DOI:
EISSN:
1741-7015
ISSN:
1741-7015
Source identifiers:
480833
Language:
English
Keywords:
Pubs id:
pubs:480833
UUID:
uuid:51218965-4375-40cb-a2de-ffdc3b8c42a2
Local pid:
pubs:480833
Deposit date:
2014-09-09

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