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The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life

Abstract:

BACKGROUND: Recent transcriptomic studies revived a hypothesis suggested by historical studies in rabbits that the ratio of peripheral blood monocytes to lymphocytes (ML) is associated with risk of tuberculosis (TB) disease. Recent data confirmed the hypothesis in cattle and in adults infected with HIV. METHODS: We tested this hypothesis in 1,336 infants (540 HIV-infected, 796 HIV-exposed, uninfected (HEU)) prospectively followed in a randomized controlled trial of isoniazid prophylaxis in So...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12916-014-0120-7

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Cotton, MF More by this author
Violari, A More by this author
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Funding agency for:
Naranbhai, V
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Funding agency for:
Mcshane, H
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Funding agency for:
Hill, AV
National Institute of Child Health and Human Development More from this funder
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Medicine Journal website
Volume:
12
Issue:
1
Pages:
Article no. 120
Publication date:
2014
DOI:
EISSN:
1741-7015
ISSN:
1741-7015
URN:
uuid:51218965-4375-40cb-a2de-ffdc3b8c42a2
Source identifiers:
480833
Local pid:
pubs:480833

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