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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

Abstract:

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chro...

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Publication status:
Published

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Publisher copy:
10.1038/ng.687

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Journal:
Nature genetics
Volume:
42
Issue:
11
Pages:
978-984
Publication date:
2010-11-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
94605

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