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Journal article

Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels.

Abstract:

Sulphonylureas are a class of drugs widely used to treat non-insulin-dependent diabetes mellitus. These drugs act by binding to a sulphonylurea receptor (SUR) in the pancreatic beta-cell membrane which inhibits an ATP-sensitive potassium (K-ATP) channel and thereby stimulates insulin secretion. There has been much debate as to whether SUR and the K-ATP channel are the same or separate proteins, whether SUR confers ATP-sensitivity on an ATP-insensitive pore-forming subunit, and whether sulphon...

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Publication status:
Published

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Publisher copy:
10.1038/379545a0

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Journal:
Nature
Volume:
379
Issue:
6565
Pages:
545-548
Publication date:
1996-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:50fa55ee-6295-456d-b3cb-0cbdd90e125e
Source identifiers:
114022
Local pid:
pubs:114022

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