- Abstract:
-
Steroid sulphatase is an emerging drug target for the endocrine therapy of hormone-dependent diseases, catalysing oestrogen sulphate hydrolysis to oestrogen. Drug discovery, developing the core aryl O-sulphamate pharmacophore, has led to steroidal and non-steroidal drugs entering numerous clinical trials, with promising results in oncology and women’s health. Steroidal oestrogen sulphamate derivatives were the first irreversible active-site-directed inhibitors and one was developed clinically...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.5mb)
-
- Publisher copy:
- 10.1530/jme-18-0045
-
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- Publisher:
- BioScientifica Publisher's website
- Journal:
- Journal of Molecular Endocrinology Journal website
- Volume:
- 61
- Issue:
- 2
- Pages:
- T233-T252
- Publication date:
- 2018-08-01
- Acceptance date:
- 2018-04-04
- DOI:
- EISSN:
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1479-6813
- ISSN:
-
0952-5041
- Pubs id:
-
pubs:835038
- URN:
-
uri:50f83f5d-deec-4d5c-aa3c-5aa55fee79bf
- UUID:
-
uuid:50f83f5d-deec-4d5c-aa3c-5aa55fee79bf
- Local pid:
- pubs:835038
- Language:
- English
- Keywords:
- Copyright holder:
- Society for Endocrinology
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Society for Endocrinology. This is the accepted manuscript version of the article. The final version is available online from BioScientifica at: https://doi.org/10.1530/jme-18-0045
Journal article
SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects
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