Journal article icon

Journal article

SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects

Abstract:

Steroid sulphatase is an emerging drug target for the endocrine therapy of hormone-dependent diseases, catalysing oestrogen sulphate hydrolysis to oestrogen. Drug discovery, developing the core aryl O-sulphamate pharmacophore, has led to steroidal and non-steroidal drugs entering numerous clinical trials, with promising results in oncology and women’s health. Steroidal oestrogen sulphamate derivatives were the first irreversible active-site-directed inhibitors and one was developed clinically...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1530/jme-18-0045

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
ORCID:
0000-0003-3255-9135
More from this funder
Funding agency for:
Potter, BVL
Publisher:
BioScientifica Publisher's website
Journal:
Journal of Molecular Endocrinology Journal website
Volume:
61
Issue:
2
Pages:
T233-T252
Publication date:
2018-08-01
Acceptance date:
2018-04-04
DOI:
EISSN:
1479-6813
ISSN:
0952-5041
Pubs id:
pubs:835038
URN:
uri:50f83f5d-deec-4d5c-aa3c-5aa55fee79bf
UUID:
uuid:50f83f5d-deec-4d5c-aa3c-5aa55fee79bf
Local pid:
pubs:835038

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP