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Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome

Abstract:

Previous articles in Statistics in Medicine describe how to calculate the sample size required for external validation of prediction models with continuous and binary outcomes. The minimum sample size criteria aim to ensure precise estimation of key measures of a model's predictive performance, including measures of calibration, discrimination, and net benefit. Here, we extend the sample size guidance to prediction models with a time-to-event (survival) outcome, to cover external validation i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/sim.9275

Authors


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Role:
Author
ORCID:
0000-0001-8699-0735
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0002-2772-2316
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Role:
Author
ORCID:
0000-0001-7481-0282
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Role:
Author
ORCID:
0000-0003-2504-2613
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Role:
Author
ORCID:
0000-0003-1799-3144
Publisher:
Wiley
Journal:
Statistics in Medicine More from this journal
Volume:
41
Issue:
7
Pages:
1280-1295
Place of publication:
England
Publication date:
2021-12-16
Acceptance date:
2021-11-16
DOI:
EISSN:
1097-0258
ISSN:
0277-6715
Pmid:
34915593
Language:
English
Keywords:
Pubs id:
1228680
Local pid:
pubs:1228680
Deposit date:
2022-08-14

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