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Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT.

Abstract:

OBJECTIVE: ADOPT (A Diabetes Outcome Progression Trial) demonstrated that initial monotherapy with rosiglitazone provided superior durability of glycemic control compared with metformin and glyburide in patients with recently diagnosed type 2 diabetes. Herein, we examine measures of β-cell function and insulin sensitivity from an oral glucose tolerance test (OGTT) over a 4-year period among the three treatments. RESEARCH DESIGN AND METHODS: Recently diagnosed, drug-naïve patients with type 2...

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Publication status:
Published

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Publisher copy:
10.2337/db10-1392

Authors


Journal:
Diabetes
Volume:
60
Issue:
5
Pages:
1552-1560
Publication date:
2011-05-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
146700
Language:
English
Keywords:
Pubs id:
pubs:146700
UUID:
uuid:50b7f3de-33e8-4044-bf60-71c50ca6e586
Local pid:
pubs:146700
Deposit date:
2012-12-19

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