Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.

Journal article

To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

Authors: Honeyborne, I; Prendergast, A; Pereyra, F; Leslie, A; Crawford, H

• Publication status: Published
• Journal: Journal of virology
• Volume: 81
• Issue: 7
• Pages: 3667-3672
• Publication date: 2007-04-01
• DOI: 10.1128/jvi.02689-06
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Gene Products, gag; Mutation; HLA-B13 Antigen; CD8-Positive T-Lymphocytes; Epitopes, T-Lymphocyte; Humans; Molecular Sequence Data; HIV-1; HLA-B Antigens; Amino Acid Sequence