Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.

Journal article

One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.

Authors: Schneider, J; Gilbert, S; Hannan, C; Dégano, P; Prieur, E

• Publication status: Published
• Journal: Immunological reviews
• Volume: 170
• Issue: 1
• Pages: 29-38
• Publication date: 1999-08-01
• DOI: 10.1111/j.1600-065x.1999.tb01326.x
• EISSN: 1600-065X
• ISSN: 0105-2896
• Language: English
• Keywords: Animals; Immunization, Secondary; Malaria Vaccines; Mice; Adjuvants, Immunologic; Epitopes; CD8-Positive T-Lymphocytes; Primates; Humans; Genetic Vectors; Malaria; Vaccines, DNA