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Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.

Abstract:

One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Immunological reviews
Volume:
170
Issue:
1
Pages:
29-38
Publication date:
1999-08-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:4ffe0113-f1d3-4c84-a67a-9c8e9a0b13b0
Source identifiers:
31577
Local pid:
pubs:31577

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