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Actin foci facilitate activation of the phospholipase C-gamma in primary T lymphocytes via the WASP pathway

Abstract:

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is negligible effect on actin polymerization at the immunological synapse, leading to gaps in our understanding of the events connecting WASP and calcium ion signaling. Here, we identify a fraction of t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.04953

Authors


Sudha Kumari More by this author
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Department:
Orthopedics
Roberta Martinelli More by this author
Edward Judokusumo More by this author
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife
Volume:
March 2015
Publication date:
2015-11-03
Acceptance date:
2015-09-02
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Source identifiers:
e04953

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