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Phosphodiesterases and compartmentalized cAMP signalling in the heart.

Abstract:

A key feature of the cAMP/cAMP-dependent protein kinase (PKA) transduction system is the compartmentalisation of its signalling enzymes and effectors. Given the large diversity of PKA targets within cardiac cells a precisely regulated and confined activity of such signalling pathway is essential for specificity of response. This appears to be achieved through the generation of local pools of high cAMP and activation of PKA at discrete subcellular locations. Phosphodiesterases (PDEs) are the o...

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Publisher copy:
10.1016/j.ejcb.2006.01.002

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
European journal of cell biology
Volume:
85
Issue:
7
Pages:
693-697
Publication date:
2006-07-05
DOI:
EISSN:
1618-1298
ISSN:
0171-9335
URN:
uuid:4fde2c2a-d436-43ee-be39-98afe96c05aa
Source identifiers:
237873
Local pid:
pubs:237873

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