A key feature of the cAMP/cAMP-dependent protein kinase (PKA) transduction system is the compartmentalisation of its signalling enzymes and effectors. Given the large diversity of PKA targets within cardiac cells a precisely regulated and confined activity of such signalling pathway is essential for specificity of response. This appears to be achieved through the generation of local pools of high cAMP and activation of PKA at discrete subcellular locations. Phosphodiesterases (PDEs) are the o...Expand abstract
- Publisher copy:
- Copyright date:
Phosphodiesterases and compartmentalized cAMP signalling in the heart.
If you are the owner of this record, you can report an update to it here: Report update to this record