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Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Abstract:

Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to activate the Pik3ca H1047R hotspot mutation in the heterozygous state from its endogenous locus, we here report that mutant Pik3ca induces centrosome amplification in cultured cells (through a pathway involving AKT, ROCK and CDK2/Cyclin E-nucleophosmin) and in mouse tissues, and incre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-02002-4

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Role:
Author
ORCID:
0000-0001-9537-4045
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European Union More from this funder
European Molecular Biology Organization More from this funder
Ong Hin Tiang and Ong Sek Pek Foundation More from this funder
Spanish Ministry of Economy and Innovation More from this funder
Catalan Government More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
1773
Publication date:
2017-11-05
Acceptance date:
2017-11-01
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:802690
URN:
uri:4fbb5836-e555-46e9-b7bf-39ad31297fb6
UUID:
uuid:4fbb5836-e555-46e9-b7bf-39ad31297fb6
Local pid:
pubs:802690
Language:
English
Keywords:

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