Journal article
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Abstract:
-
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To understand the structural basis of proline import, we solved the structure of the proline transporter SIT1 in complex with the COVID-19 viral receptor ACE2 by cryo-electron microscopy. The structure of pipecolate-bound SIT1 reveals the specific sequence ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41467-024-48921-x
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Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 15
- Issue:
- 1
- Article number:
- 5503
- Publication date:
- 2024-06-29
- Acceptance date:
- 2024-05-16
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
Item Description
- Language:
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English
- Pubs id:
-
2011492
- Local pid:
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pubs:2011492
- Source identifiers:
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2081606
- Deposit date:
-
2024-07-02
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