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Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.

Abstract:

BACKGROUND: Stress-induced hypertrophic remodeling is a critical pathogenetic process leading to heart failure. Although many signal transduction cascades are demonstrated as important regulators to facilitate the induction of cardiac hypertrophy, the signaling pathways for suppressing hypertrophic remodeling remain largely unexplored. In this study, we identified p21-activated kinase 1 (Pak1) as a novel signaling regulator that antagonizes cardiac hypertrophy. METHODS AND RESULTS: Hypertroph...

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Publication status:
Published

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Authors


Naumann, R More by this author
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Journal:
Circulation
Volume:
124
Issue:
24
Pages:
2702-2715
Publication date:
2011-12-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:4fa4b674-3cb1-4d06-8114-e7e59734c471
Source identifiers:
418440
Local pid:
pubs:418440

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