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Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

Abstract:

NF-kappaB transcription factors induce pro-inflammatory molecules (e.g. IL-8) in response to cytokines (e.g. TNFalpha, IL-1beta) or other stimuli. In the basal state, they are sequestered in the cytoplasm by inhibitory IkappaB proteins. Pro-inflammatory signaling triggers polyubiquitination of intermediaries (e.g. RIP1), which activate IkappaB kinases that trigger Ser phosphorylation and degradation of IkappaBalpha, thereby promoting nuclear translocation of NF-kappaB. A negative feedback loo...

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Publisher copy:
10.1074/jbc.m801312200

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Journal:
The Journal of biological chemistry
Volume:
283
Issue:
27
Pages:
18582-18590
Publication date:
2008-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:4fa3a4da-451b-44a1-bdab-659eb124b65c
Source identifiers:
244471
Local pid:
pubs:244471

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