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Journal article

The adult human testis transcriptional cell atlas

Abstract:

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility and faithful genome propagation. Here, we performed single-cell RNA sequencing of ~6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig, myoid, Sertoli, endothelial, macrophage), and observed germline-niche interactions and key human-mouse differences. Spermatogenesis, including me...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41422-018-0099-2

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
ORCID:
0000-0001-7135-4824
Lindskog, C More by this author
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Grant:
Senior Investigator Award 102731 to Prof. Andrew Wilkie supports A.G., G.J.M., and H.M.
Publisher:
Springer Nature Publisher's website
Journal:
Cell Research Journal website
Volume:
28
Pages:
1141–1157
Publication date:
2018-10-12
Acceptance date:
2018-09-19
DOI:
EISSN:
1748-7838
ISSN:
1001-0602
Pubs id:
pubs:927577
URN:
uri:4fa340a1-d0c1-4710-a9a7-297b027e8527
UUID:
uuid:4fa340a1-d0c1-4710-a9a7-297b027e8527
Local pid:
pubs:927577
Language:
English

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