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Mechanisms of creatine depletion in chronically failing rat heart.

Abstract:

The failing myocardium is characterised by energetic imbalance, reflected by reduced phosphocreatine and creatine content. These changes may contribute to cardiac dysfunction, yet mechanisms of creatine and phosphocreatine depletion are poorly understood. Creatine is taken up by the heart via the creatine transporter. We investigated the mechanisms leading to myocardial creatine depletion in heart failure. Therefore rats were subjected to chronic left coronary artery ligation (MI; n = 36) or ...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2004.11.016

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Volume:
38
Issue:
2
Pages:
309-313
Publication date:
2005-02-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:4f8ca784-9e84-4381-8324-6936af9478f0
Source identifiers:
151742
Local pid:
pubs:151742

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