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Journal article

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1

Abstract:

Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread. We show here that Metastasis suppressor-1 (Mtss1; Missing in Metastasis, MIM), a member of the IMD-family of proteins, inhibits cell-cell junction disassembly in wound healing or HGF-induced scatter assays by enhancing cell-cell junction strength. Mtss1 not only makes cells more resistant to cell-cell junc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0031141

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Cancer Research UK More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
7
Issue:
3
Pages:
e31141
Publication date:
2012-03-27
Acceptance date:
2012-01-03
DOI:
EISSN:
1932-6203
Pubs id:
pubs:632590
URN:
uri:4f7c69a3-ca2a-44d4-aeae-c8764aa37cdb
UUID:
uuid:4f7c69a3-ca2a-44d4-aeae-c8764aa37cdb
Local pid:
pubs:632590
Paper number:
3

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