Journal article
Insights into malaria susceptibility using genome - wide data on 17,000 individuals from Africa, Asia and Oceania
- Abstract:
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The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for arou...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 5.1MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-019-13480-z
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Funding
Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 10
- Article number:
- 5732
- Publication date:
- 2019-12-16
- Acceptance date:
- 2019-11-11
- DOI:
- EISSN:
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2041-1723
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1071344
- UUID:
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uuid:4f6fa1d6-210c-48f0-8955-b103dbfa4382
- Local pid:
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pubs:1071344
- Source identifiers:
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1071344
- Deposit date:
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2019-11-12
Terms of use
- Copyright holder:
- Band et al.
- Copyright date:
- 2019
- Rights statement:
- Copyright © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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