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Journal article

Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.

Abstract:

CONTEXT: A number of small data sets have suggested a potential role for skewed X chromosome activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation for the strong female preponderance seen in the common autoimmune thyroid diseases (AITD), Graves' disease (GD), and Hashimoto's thyroiditis (HT). OBJECTIVE: The objective of the study was to confirm a role for XCI skewing as a potential explanation for the strong female preponderance seen in AITD. DESIGN: The des...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2013-2667

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Kavvoura, FK More by this author
Jackson, LE More by this author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
99
Issue:
1
Pages:
E127-E131
Publication date:
2014-01-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:4f6140d3-105a-49d6-9990-5cdffc082b13
Source identifiers:
438725
Local pid:
pubs:438725

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