Journal article

Polymyxin B1 within the E. coli cell envelope: insights from molecular dynamics simulations

Abstract:: Polymyxins are used as last-resort antibiotics, where other treatments have been ineffectual due to antibiotic resistance. However, resistance to polymyxins has also been now reported, therefore it is instructive to characterise at the molecular level, the mechanisms of action of polymyxins. Here we review insights into these mechanisms from molecular dynamics simulations and discuss the utility of simulations as a complementary technique to experimental methodologies

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Weerakoon, D., Petrov, K., Pedebos, C., & Khalid, S. (2021). Polymyxin B1 within the E. coli cell envelope: insights from molecular dynamics simulations. Biophysical Reviews, 13(6), 1061–1070.

MLA Style

Weerakoon, D, et al. “Polymyxin B1 within the E. Coli Cell Envelope: Insights from Molecular Dynamics Simulations.” Biophysical Reviews, vol. 13, no. 6, 2021, pp. 1061–70.

Chicago Style

Weerakoon, D, K Petrov, C Pedebos, and S Khalid. 2021. “Polymyxin B1 within the E. Coli Cell Envelope: Insights from Molecular Dynamics Simulations.” Biophysical Reviews 13 (6): 1061–70.
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Files:: Weerakoon_et_al_2021_Polymyxin_B1_within.pdf

(Preview, Version of record, pdf, 1.5MB, Terms of use)

Publisher copy:: 10.1007/s12551-021-00869-8

Authors

+ Weerakoon, D More by this author

Role:: Author

+ Petrov, K More by this author

Institution:: University of Oxford
Oxford college:: Hertford College
Role:: Author

+ Pedebos, C More by this author

Institution:: University of Oxford
Role:: Author
ORCID:: 0000-0003-0378-4851

+ Khalid, S More by this author

Institution:: University of Oxford
Role:: Author
ORCID:: 0000-0002-3694-5044

Publisher:: Springer
Journal:: Biophysical Reviews More from this journal
Volume:: 13
Issue:: 6
Pages:: 1061-1070
Publication date:: 2021-11-22
DOI:: 10.1007/s12551-021-00869-8
EISSN:: 1867-2469
ISSN:: 1867-2450

Language:: English
Keywords:: Cell biology

Antibiotics

Polymyxin B

Biology

Chemistry

Molecular cell biology

Microbiology

Computational biology

Polymyxin
Pubs id:: 1212729
Local pid:: pubs:1212729
Source identifiers:: W3216723889
Deposit date:: 2026-05-22
ARK identifier:: ark:/29072/ora_4f341f96d58a4cf1905002a86a510c33

Terms of use

Copyright date:: 2021

Licence:: CC Attribution (CC BY)

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