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Sodium channel heterologous expression in mammalian cells and the role of the endogenous beta1-subunits.

Abstract:

Sodium currents in cell lines transfected with the sole alpha-subunit, or constitutively expressing sodium channels, have an inactivation that is always prevalently mono-exponential. Differently, expression of alpha-subunit in Xenopus oocytes exerts slow inactivating currents with biphasic decay, while simultaneous co-transfection of alpha and beta1 restores a mono-exponential (normal) inactivation. A hypothesis for such differences is that an endogenous presence of beta1 or beta1-alternative...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuroscience letters
Volume:
336
Issue:
3
Pages:
175-179
Publication date:
2003-01-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:4f32602e-6851-41ad-8b85-5bf19c273f78
Source identifiers:
386841
Local pid:
pubs:386841

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