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Benchmarking stable isotope labeling based quantitative proteomics.

Abstract:

Several quantitative mass spectrometry based technologies have recently evolved to interrogate the complexity, interconnectivity and dynamic nature of proteomes. Currently, the most popular methods use either metabolic or chemical isotope labeling with MS based quantification or chemical labeling using isobaric tags with MS/MS based quantification. Here, we assess the performance of three of the most popular approaches through systematic independent large scale quantitative proteomics experim...

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Journal:
Journal of proteomics
Volume:
88
Pages:
14-26
Publication date:
2013-08-02
EISSN:
1876-7737
URN:
uuid:4f2d4ce8-8a08-4eb3-952a-54f0019ee9a6
Source identifiers:
450833
Local pid:
pubs:450833
Language:
English

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