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Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: Deviations from Hardy-Weinberg equilibrium

Abstract:

Our objective was to compare observed and expected genotype proportions from newborn screening surveys of structural hemoglobin variants.We conducted a systematic review of newborn screening surveys of hemoglobins S and C in Africa and the Middle East. We compared observed frequencies to those expected assuming Hardy-Weinberg equilibrium (HWE). Significant deviations were identified by an exact test. The fixation index FIS was calculated to assess excess homozygosity. We compared newborn esti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/gim.2015.143

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Genetics in Medicine Journal website
Volume:
18
Issue:
3
Pages:
265-274
Publication date:
2015-12-03
Acceptance date:
2015-08-25
DOI:
EISSN:
1530-0366
ISSN:
1530-0366
URN:
uuid:4f2466a7-5a9c-4bc0-ba64-eb2bf9ade6c3
Source identifiers:
571060
Local pid:
pubs:571060

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