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Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur.

Abstract:

Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell surface receptor implicated in tumour suppression. Its growth inhibitory activity has been associated with an ability to bind IGF-II. IGF2R contains 15 homologous extracellular domains, with domain 11 primarily responsible for IGF-II binding. We report a 1.4 A resolution crystal structure of domain 11, solved using the anomalous scattering signal of sulfur. The structure consists of two crossed beta-sheets forming a flat...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/21.5.1054

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Linnell, J More by this author
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Journal:
The EMBO journal
Volume:
21
Issue:
5
Pages:
1054-1062
Publication date:
2002-03-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:4f109573-85a1-4e2c-89db-35115cc9765b
Source identifiers:
23133
Local pid:
pubs:23133

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