Prophylactic platelet transfusions

Journal article

Purpose of review: This review highlights the recent research on the use of prophylactic platelet transfusions, which is a topic that still provokes controversy. Over the last 12 months, there have been several studies with important new findings. Recent findings: Two randomized controlled trials compared different doses of prophylactic platelet transfusions in patients with haematological malignancies. In neonates, platelet mass has been used as a trigger for prophylactic platelet transfusions rather than the morning platelet count; and interim results of a therapeutic vs. a prophylactic platelet-transfusion strategy in acute myeloblastic leukaemia have been published. Summary: Low-dose prophylactic platelet transfusions are as effective in the prevention of bleeding as high-dose platelets. Fewer platelets were transfused but more frequent transfusions were required. Platelet mass as a transfusion trigger led to a lower prophylactic platelet requirement and did not increase the risk of bleeding in thrombocytopenic neonates. The interim results of the trial of a therapeutic vs. a prophylactic transfusion strategy were unable to provide any firm conclusion about their relative effectiveness and further information is required from ongoing trials. © 2010 Wolters Kluwer Health | Lippincott Williams and Wilkins.

Authors: Estcourt, L; Stanworth, S; Murphy, M

• Journal: Current Opinion in Hematology
• Volume: 17
• Issue: 5
• Pages: 411-417
• Publication date: 2010-09-01
• DOI: 10.1097/MOH.0b013e32833c07e8
• EISSN: 1531-7048
• ISSN: 1065-6251
• Language: English
• Keywords: transfusion; thrombocytopenia; prophylactic transfusion; dose; platelets