Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.

Journal article

BACKGROUND: Anxiety disorders are common psychiatric conditions that are highly comorbid with each other and related phenotypes such as depression, likely due to a shared genetic basis. Fear-related behaviors in mice have long been investigated as potential models of anxiety disorders, making integration of information from both murine and human genetic data a powerful strategy for identifying potential susceptibility genes for these conditions. METHODS: We combined genome-wide association an...

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Authors: Hettema, J; Webb, B; Guo, A; Zhao, Z; Maher, B

• Publication status: Published
• Journal: Biological psychiatry
• Volume: 70
• Issue: 9
• Pages: 888-896
• Publication date: 2011-11-01
• DOI: 10.1016/j.biopsych.2011.07.012
• EISSN: 1873-2402
• ISSN: 0006-3223
• Language: English
• Keywords: Genome-Wide Association Study; Diagnostic and Statistical Manual of Mental Disorders; Data Interpretation, Statistical; Mice, Knockout; Genotype; Animals; Transcription Factors; Polymorphism, Single Nucleotide; Behavior, Animal; Anxiety Disorders; Heat-Shock Proteins; Mice; Humans; Fear; Genetic Linkage; Databases, Genetic