Journal article

Quiescence as a mechanism for cyclical hypoxia and acidosis

Abstract:: Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variations in substrate levels were assumed to occur through oscillations in the h ae modynamics of nearby and distant blood vessels. In this paper we examine an alternative hypothesis, that cycles of metabolite concentrations are also driven by cycles of cellular quiescence and proliferation. Using a mathemat

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APA Style

Smallbone, K., Gavaghan, D., Maini, P., & Brady, J. (2007). Quiescence as a mechanism for cyclical hypoxia and acidosis. JOURNAL OF MATHEMATICAL BIOLOGY    , 55(5), 767–779.

MLA Style

Smallbone, K., et al. “Quiescence as a Mechanism for Cyclical Hypoxia and Acidosis.” JOURNAL OF MATHEMATICAL BIOLOGY    , vol. 55, no. 5, 2007, pp. 767–79.

Chicago Style

Smallbone, K, D Gavaghan, P Maini, and J Brady. 2007. “Quiescence as a Mechanism for Cyclical Hypoxia and Acidosis.” JOURNAL OF MATHEMATICAL BIOLOGY     55 (5): 767–79.
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Authors

+ Smallbone, K More by this author

Role:: Author

+ Gavaghan, D More by this author

Role:: Author

+ Maini, P More by this author

Role:: Author

+ Brady, J More by this author

Role:: Author

Journal:: JOURNAL OF MATHEMATICAL BIOLOGY More from this journal
Volume:: 55
Issue:: 5
Pages:: 767-779
Publication date:: 2007-11-01

UUID:: uuid:4ecee97d-a1cb-4974-bb9a-134b3d2bffd5
Local pid:: cs:4244
Deposit date:: 2015-03-31

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Copyright date:: 2007

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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