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DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Abstract:

Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, using live single-cell measurements of p21 protein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase causes p53-dependent accumulation of p21 during mother G...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms14728

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Department:
Oxford, MSD, Biochemistry
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
14728
Publication date:
2017-03-20
Acceptance date:
2017-01-26
DOI:
EISSN:
2041-1723
Pubs id:
pubs:686688
URN:
uri:4ec77933-5289-4c3e-9994-18344334f5c4
UUID:
uuid:4ec77933-5289-4c3e-9994-18344334f5c4
Local pid:
pubs:686688
Language:
English
Keywords:

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