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Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?

Abstract:

Socio-economic factors have led to an increasing trend for couples to delay parenthood. However, advancing age exerts detrimental effects upon gametes which can have serious consequences upon embryo viability. While such effects are well documented for the oocyte, relatively little is known with regard to the sperm. One fundamental role of sperm is to activate the oocyte at fertilisation, a process initiated by phospholipase C zeta (PLCζ), a sperm-specific protein. While PLCζ deficiency can l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep27543

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Yelumalai, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
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Funding agency for:
Yeste, M
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
Article: 27543
Publication date:
2016
DOI:
ISSN:
2045-2322
URN:
uuid:4ebe1af3-e029-40a5-8ec4-921119fc7a57
Source identifiers:
623805
Local pid:
pubs:623805

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