- Abstract:
-
In interleukin-23 (IL-23)-dependent colitis, there is excessive accumulation of short-lived neutrophils and inflammatory monocytes in the intestine. It is unknown whether this reflects changes in mature cell populations or whether the IL-23-driven colitogenic T cell program regulates upstream hematopoietic stem and progenitor cells (HSPC). Here we have shown dysregulation of hematopoiesis in colitis mediated by inflammatory cytokines. First, there was an interferon-gamma-dependent accumulatio...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.immuni.2012.08.025
-
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- Journal:
- IMMUNITY
- Volume:
- 37
- Issue:
- 6
- Pages:
- 1116-1129
- Publication date:
- 2012-12-14
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- URN:
-
uuid:4eba439b-bb40-4e21-8447-8268d635d12f
- Source identifiers:
-
368104
- Local pid:
- pubs:368104
- Copyright date:
- 2012
Journal article
Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation
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