Linkage of the loci for glucose-6-phosphate dehydrogenase and for inosinic acid pyrophosphorylase to the X chromosome of the field-vole Microtus agrestis.

Journal article

It has been proposed that there are strong selective pressures which have acted during the evolution of mammals to conserve the linkage of genes on the X chromosome. If so, loci that are known to be X-linked in one mammalian species should be X-linked in others. The loci for glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49) and for inosinic acid pyrophosphorylase (E.C. 2.4.2.8) are known to be X-linked in a variety of mammals. The linkage of these loci to the X chromosome of the field-vole, Microtus agrestis, is indicated by the pattern of segregation of these loci in hybrid cells derived by fusion of mouse cells with vole lymphocytes.

Authors: Cook, P

• Publication status: Published
• Journal: Journal of cell science
• Volume: 17
• Issue: 1
• Pages: 95-112
• Publication date: 1975-01-01
• EISSN: 1477-9137
• ISSN: 0021-9533
• Language: English
• Keywords: Thymidine; Tritium; Inosine Monophosphate; Aminopterin; Culture Media; Fibroblasts; Rodentia; L Cells (Cell Line); Male; Karyotyping; Animals; Female; Pentosyltransferases; Cell Fusion; Hypoxanthines; Genes; Culture Techniques; Thioguanine; Mice; Electrophoresis; Glucosephosphate Dehydrogenase; Autoradiography; Lymphocytes; Hybrid Cells; Genetic Linkage; Sex Chromosomes