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ADF/cofilin controls cell polarity during fibroblast migration.

Abstract:

To migrate, normally a cell must establish morphological polarity and continuously protrude a single lamellipodium, polarized in the direction of migration. We have previously shown that actin filament disassembly is necessary for protrusion of the lamellipodium during fibroblast migration. As ADF/cofilin (AC) proteins are essential for the catalysis of filament disassembly in cells, we assessed their role in polarized lamellipodium protrusion in migrating fibroblasts. We compared the spatial...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Minamide, LS More by this author
Bamburg, JR More by this author
Cramer, LP More by this author
Journal:
Current biology : CB
Volume:
13
Issue:
3
Pages:
252-257
Publication date:
2003-02-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:4eb5db5a-c825-4f60-8f91-e372cae94992
Source identifiers:
30419
Local pid:
pubs:30419

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