Journal article icon

Journal article

Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives.

Abstract:

The (thio)carboxanilide derivatives are potent and selective inhibitors of HIV-1 reverse transcriptase (RT) and have a favourable antiviral activity spectrum. To understand better their mode of action, and to provide a structural basis for further improvement, models of RT complexed with four (thio)carboxanilide inhibitors (UC781, UC10, UC38 and UC84) have been constructed based on the X-ray structure of RT complexed with 9-chloro-TIBO. In the models, the protein conformation is similar to th...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1006/bbrc.1997.6552

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
De Clercq, E More by this author
Schwartz, E More by this author
Balzarini, J More by this author
Journal:
Biochemical and biophysical research communications
Volume:
234
Issue:
2
Pages:
458-464
Publication date:
1997-05-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:4e8aeed3-4934-4c02-9950-b0951d29e6c6
Source identifiers:
24422
Local pid:
pubs:24422

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP