Journal article
Effect of Modified Vaccinia Ankara–5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial
- Abstract:
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Importance:The success of immunotherapy with checkpoint inhibitors is not replicated in most cases of colorectal cancer; therefore, different strategies are urgently required. The oncofetal antigen 5T4 is expressed in more than 90% of cases of metastatic colorectal cancer (mCRC). Preliminary data using modified vaccinia Ankara-5T4 (MVA-5T4) in mCRC demonstrated that it safely induced serologic and T-cell responses. Objective:To determine whether antitumor immunity in mCRC could be increased u...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 550.3KB, Terms of use)
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- Publisher copy:
- 10.1001/jamaoncol.2017.2579
Authors
- Publisher:
- American Medical Association
- Journal:
- JAMA Oncology More from this journal
- Volume:
- 3
- Issue:
- 10
- Article number:
- e172579
- Publication date:
- 2017-09-07
- Acceptance date:
- 2017-06-14
- DOI:
- ISSN:
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2374-2445 and 2374-2437
- Pmid:
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28880972
- Language:
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English
- Keywords:
- Pubs id:
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pubs:729955
- UUID:
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uuid:4e25dcbf-3802-4281-a517-b76e7c16350d
- Local pid:
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pubs:729955
- Source identifiers:
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729955
- Deposit date:
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2019-02-27
Terms of use
- Copyright holder:
- Scurr et al
- Copyright date:
- 2017
- Notes:
- This is an open access article distributed under the terms of the CC-BY License. © 2017 Scurr M et al. JAMA Oncology.
- Licence:
- CC Attribution (CC BY)
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