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DNA triple-helix formation at target sites containing duplex mismatches.

Abstract:

We have studied the formation of DNA triple helices at target sites that contain mismatches in the duplex target. Fluorescence melting studies were used to examine a series of parallel triple helices that contain all 64 N.XZ triplet combinations at the centre (where N, X and Z are each of the four natural DNA bases in turn). Similar experiments were also performed with N=bis-amino-U (BAU) (for stable recognition of AT base pairs) and N=S (for recognition of TA inversions). We find that the in...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpc.2006.04.016

Authors


Rusling, DA More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Biophysical chemistry
Volume:
123
Issue:
2-3
Pages:
134-140
Publication date:
2006-09-05
DOI:
EISSN:
1873-4200
ISSN:
0301-4622
URN:
uuid:4e236c27-d68d-4e0d-aa41-998ac80f4e63
Source identifiers:
400034
Local pid:
pubs:400034

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